Showing posts with label HIV vaccine. Show all posts
Showing posts with label HIV vaccine. Show all posts

Saturday, December 1, 2012

World Aids Day is on Saturday, December 1, 2012

Today, people around the globe will come together to recognize World AIDS Day.

14 HIV/AIDS beliefs: Which ones are true?

© US News // © US NewsAs if waging war against an incurable virus that plagues 33 million people globally weren't enough, researchers, doctors, and public health officials continue to battle yet another elusive problem as World Aids Day approaches Saturday: misinformation.

"It really does obstruct the fight," says Rowena Johnston, vice president and director of research at amfAR, a nonprofit that funds HIV/AIDS research. Broaching topics like sex and drug use­­ -- the major vehicles for transmission -- is "taboo" for many, she says, "so a challenge certainly is getting people to talk openly and honestly about what HIV is and isn't." And part of a candid conversation should be devoted to debunking the myths many have come to believe, including the following:

1. If I had HIV, I would know

Not the case, says Kimberley Hagen, assistant director for the Center for AIDS Research at Emory University in Atlanta. About 1.1 million people in the United States are HIV-positive, and as many as 1 in 5 don't know it, estimates the Centers for Disease Control and Prevention. Many of them feel perfectly healthy. And those who have symptoms may confuse them with run-of-the-mill flu. Denial also plays a role, say experts. "There is a universal tendency with HIV," says Hagen, to try to say, " 'This is something that will affect someone else and not me.' And so you say that you can't get it doing the things that you do -- you can only get it doing the things that other people do. That may be the biggest myth."

2. HIV and AIDS are the same

False: HIV is the virus that leads to AIDS. You could have HIV for years without having AIDS.

3. I don't have to worry because I'm not in a high-risk group

While prostitutes, men who have sex with men, and needle sharers are considered at high risk by the CDC, the virus is an equal-opportunity bug. "Many people don't perceive themselves to be at risk and so don't understand why testing is important," says Joel Gallant, associate director of the AIDS Service at Johns Hopkins Hospital in Baltimore. One example: Heterosexuals account for a third of new HIV transmissions each year, the CDC reports, and a woman might not know her male partner has slept with men in the past or has shared needles with an infected user. Monogamous relationships don't guarantee absolute safety unless you've both been tested and are HIV-negative. In rare instances, women who have sex with women can pass on the virus. And the number of people 50 and older living with HIV/AIDS is on the rise, partly due to newly diagnosed infections, says Paul Weidle, an epidemiologist with the CDC. There are no hallmark characteristics to watch out for, no physical attribute that will "set off an alarm in your head saying 'this person has HIV,' " says Hagen.

4. We're both HIV-positive

We don't need to practice safe sex. Wrong, says Weidle. Superinfection -- where someone gets infected with a different strain of the virus -- is possible. This new strain could be drug-resistant and even stimulate the transition to full-blown AIDS. Not to mention that shunning condoms leaves the body open to other sexually transmitted diseases that an already weakened immune system can't fight off. Birth control also doesn't protect against HIV.

5. HIV transmission by someone on antiretroviral drugs is impossible

While the drugs can lower the amount of virus -- the "viral load" -- in the blood to an undetectable level, it could still register in semen or vaginal fluid and be passed on, says Gallant. Doctors usually test viral load every three to six months, and while chances are "pretty slim" that an undetectable level would suddenly rise, says Gallant, it is possible.

6. I'm sure my doctor has tested me and would have told me if the results were positive

Healthcare professionals will not test you without first talking about it, says Hagen. The CDC recommends at least one test for everyone between the ages of 13 and 64, and those considered high risk should be tested multiple times. Ask your primary-care physician or find a testing center by Zip code here.

7. I won't get HIV through oral sex

Transmission is less common than through anal or vaginal sex, but it is still possible whether performing or receiving oral sex, says Weidle.

. I can get HIV through casual contact or kissing

This belief has persisted from the dawn of the epidemic in the early 1980s. HIV is transmitted through blood, semen, vaginal fluid, and breast milk. You cannot get HIV by shaking hands or hugging, nor can you get it from a toilet seat, drinking fountain, or drinking glasses, says Weidle. HIV does not travel through air or food and cannot live long outside the body. Closed-mouth kissing is also safe, but Weidle notes there have been "extremely rare cases of HIV being transmitted via deep French kissing." In these cases, bleeding gums or sores in the mouth were the conduits.

9. I'm HIV-positive but feel fine

I don't need antiretroviral drugs. "That's very old-fashioned thinking," says Gallant. "Nowadays there's really pretty good evidence that everybody with HIV, or just about everybody, would benefit from treatment in some way." And the point of treatment is to prevent an infected person from getting sick.

10. HIV-positive mothers pass the virus on to their babies

While the CDC estimates that mothers who aren't on antiretroviral treatment have a 25 percent chance of passing the infection on to a newborn, faithful drug therapy during the pregnancy can drop that to 2 percent or less. Women with HIV and AIDS can still have children.

11. I can't get HIV through tattoos or body piercing

If a tattoo parlor or piercing place doesn't sterilize its equipment properly, the virus could inadvertently be transmitted. Tools that cut the skin should be used only once and then either thrown away or sterilized, the CDC recommends, and a new needle should be used on each client. Before getting a tattoo or piercing, ask what steps the shop takes to prevent HIV and other infections, such as hepatitis B or C.

12. I'm too young to get HIV

Au contraire, young adults ages 13 to 24 account for more than a quarter of all new HIV infections, according to a CDC report published this month. About 60 percent of those infected either don't know it or aren't being treated, which means they may be transmitting the virus to others.

13. HIV isn't that serious anymore

Many people think that since it doesn't flash across the front pages as much it's no longer a big deal, says Hagen. "It absolutely is. It's still here, it's still serious, and we don't have a cure for it."

14. Eliminating AIDS is a futile mission

Yes, the outlook sometimes appears grim. But a recent report from the Joint United Nations Programme on HIV/AIDS (UNAIDS) shows a promising development: New HIV infections have dropped 50 percent across 25 countries, and worldwide, AIDS-related deaths fell by more than 25 percent between 2005 and 2011.

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Thursday, September 29, 2011

Vaccine could reduce HIV to 'minor infection'

HIV could be reduced to a "minor chronic infection" akin to herpes, scientists developing a new vaccine have claimed.

HIV virus particles

HIV virus particles Photo: GETTY IMAGES

Spanish researchers found that 22 of 24 healthy people (92 per cent) developed an immune response to HIV after being given their MVA-B vaccine.

Professor Mariano Esteban, head researcher on the project at the National Biotech Centre in Madrid, said of the jab: "It is like showing a picture of the HIV so that it is able to recognize it if it sees it again in the future."

The injection contains four HIV genes which stimulate T and B lymphocytes, which are types of white blood cells.

Prof Esteban explained: "Our body is full of lymphocytes, each of them programmed to fight against a different pathogen.

"Training is needed when it involves a pathogen, like the HIV one, which cannot be naturally defeated".

B cells produce antibodies which attack viruses before they infect cells, while T cells detect and destroy infected cells.

The study showed that almost three-quarters of participants had developed HIV-specific antibodies 11 months after vaccination.Over a third developed one type of T cell that fights HIV, called CD4+, while over two-thirds developed another, called CD8+.

Overall, 92 per cent developed some sort of immune response. However, that is not the same thing as being protected from HIV infection: the response could be inadequate to provide protection.

Prof Esteban acknowledged the vaccine was at an early stage, describing it as "promising".

The next step is to test it in people with HIV to see if it works as a "therapeutic" - reducing the viral count.

The researcher was optimistic, saying: "MVA-B vaccine has proven to be as powerful as any other vaccine currently being studied, or even more.

"If this genetic cocktail passes Phase II and Phase III future clinic trials, and makes it into production, in the future HIV could be compared to herpes virus nowadays."

By that he meant HIV could become a "minor chronic infection" that only resulted in disease when the immune system was otherwise compromised.

Other vaccines are in development. One, called the HIV-v vaccine, developed by British researchers, resulted in a 90 per cent reduction in viral count in HIV-infected people. Most trials so far have been small scale.

There have also been many false dawns with prospective HIV vaccines.

Jason Warriner, clinical director for the Terrence Higgins Trust, described the Spanish project as "a step in the right direction".

Stephen AdamsBy Stephen Adams, Medical Correspondent - 10:00PM BST 28 Sep 2011

 

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Source:  The Telegraph